Do not take for more than 14 days or more often than every four months unless directed by a doctor. All patients should talk to their doctor before stopping or starting any medication therapy. Prilosec OTC contains omeprazole-Mg 20.6 mg, equivalent to omeprazole 20 mg, which is the leading dose strength for prescription omeprazole (Prilosec). It's a pretty safe drug, but if you need to use it for more than 14 days, you should probably see a physician about it is the point. For example, stomach ulcers are mostly caused by an infection and aggravated by acid. If that's what's bothering you, you need to see a physician to eliminate the infection. Prilosec OTC is a delayed-release 20mg tablet, taken once a day (every 24 hours) for 14 days before eating. You should not take it for more than 14 days or repeat a 14-day course more often than. *It’s possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Hi all This is my first post, so I hope I do it right. My question is can I use Prilosec OTC for longer than the 14 days the package says. Last summer I developed a condition where I have indigestion after I eat. I never understood why Prilosec says take for 14 days or 42 days. My doctor has me taking a PPI (which is what Prilosec is) for life! If I do not, my Barrett's Esophsgus which was caused by GERD will probably get worse and I could get cancer. The 14 days treatment for Prilosec is for little problems. Most ulcers, gerd etc require a longer treatment time than 14 days, and they want you to go to your doctor in case it is something more serious. Thank you for your comment. I am going to try to take it another 14 days and then try to get off of it slowly. This is my 3rd round. I know that you are supposed to wait the 4 months, but the pain comes back. The manufacturer's label for Prilosec OTC indicates that the product should not be used for more than 14 days unless directed by your doctor. The prescription Prilosec (omeprazole) was approved by.